منابع مشابه
Inborn errors of sphingolipid metabolism.
I T is my intent to gather together facts pertaming to the lipidoses which might serve to focus on current problems and to call attention to possible therapeutic approaches. The particular lipidoses to be discussed involve the accumulation in tissues of sphingolipids and may be referred to as sphingolipidoses. They may be classified as “inborn errors of sphingolipid metabolism” on the basis tha...
متن کاملDrug sensitivity and sphingolipid metabolism in CLL.
Management and outcome of patients with CLL have changed during the past decade due to improvements in molecular diagnostics and the implementation of targeted drug therapy.2,3 This rapid progress was due to the discovery of chromosomal changes, the understanding of the prognostic impact of the mutational status of immunoglobulin heavy chain genes, the discovery of prognostic markers and potent...
متن کاملSphingolipid Metabolism and Obesity-Induced Inflammation
Obesity is a metabolic disorder developed by overnutrition and a major cause for insulin resistance and cardiovascular events. Since adipose tissue is one of the major sites for the synthesis and secretion of cytokines, enlarged adipose tissue in obese condition alters inflammatory state leading to pathophysiological conditions such as type 2 diabetes and increased cardiovascular risk. A plausi...
متن کاملSphingolipid Metabolism Inhibitors and Cell Function
It has been widely shown that ceramide, ceramide phosphate, sphingosine and sphingosine-1-phosphate are molecules involved in cell proliferation, differentiation and apoptosis. The regulation of the enzymes that control their metabolism has an important role for cellular fate. Many studies in the field have shed light on sphingolipid metabolism inhibition and on its role in cell processes such ...
متن کاملRelationship between Sphingolipid and Phospholipid Metabolism
Pasternak, C. A. (1972) J. Cell Biol. 53, 231-234 Pasternak, C. A. & Bergeron, J. J. M. (1970) Biochem. J. 119, 473-480 Pasternak, C. A. & Friedrichs, B. (1970) Biochem. J. 119, 481-488 Pasternak, C. A. & Knox, P. (1973) in Membrane-Mediated Information (Kent, P. W., ed.), Medical and Technical Publishing Co., Oxford and Lancaster, in the press Pasternak, C. A. & Quinn, P. J. (1973) Biochim. Bi...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2006
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2006.06.009